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"During the 20 years that I have been treating my patients with aloe, I have found that there are many diseases described by the doctors of antiquity which disappear rapidly when I administer aloe"

Francois-Vincent Raspail
(1794-1878)

The lists

the main list  - 300 references giving title, author, and journal ref;  links to abstracts, where available

list of titles only - which gives an easy to read overview of the extent of aloe research

complete journal articles - 250 downloadable .pdf documents  

abstracts  -  120 articles listed with abstracts

clinical trials - a list of nine major clinical trials using aloe vera  


To understand more about scientific research and research methods click here

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The Research  - Clinical Trials


Clinical Trials

Click of the links to view a more detailed report on each of these trials.  

Press cuttings and anecdotal evidence on the effects of Aloe Vera can be found at the foot of the Conditions page.

Burns - 1995 

Burns healed faster with Aloe Vera gel than vaseline gauze, 12 vs. 18 days in a trial with 27 patients 


Cystitis - 1995 

Of the 8 patients who completed the six month trial, 7 patients received relief from at least some of their symptoms of pelvic pain, frequency of urination, pressure, or nocturia (87.5%). Four patients experienced significant relief from all or most of their symptoms (50%). Only one patient had no response after completing all six months of the study (12.5%). 

Chronic venous leg ulcers - 1998 

A pilot study rather than a larger clinical trial. Seven ulcers ranging in duration from four to 15 years were treated, six of which were venous leg ulcers and one in a patient with systemic lupus erythematosis.  One patent withdrew and of the remainder three of the six wounds healed completely, one healed partially  and one showed no improvement.

     
Dentistry - 2002 

The study results suggest that the SaliCept Patch (a freeze-dried pledget that contains Acemannan Hydrogel obtained from the clear inner gel of Aloe Vera) significantly reduces the incidence of  alveolar osteitis compared with clindamycin-soaked Gelfoam.  


Diabetes - 1996 

The results showed that the average (mean) blood glucose level of the patients in the Aloe juice group was significantly reduced from the second week of the study and continued to fall throughout the treatment period, whereas there were no changes reported in the placebo group. 


Psoriasis - 1996 

Slight to moderate chronic plaque-type psoriasis was cured in 4 weeks with 0.5% Aloe extract in 25/30 patients (83.3%) compared to the placebo cure rate of 2/30 (6.6%) and clearing of psoriatic plaques was 328/396 (82.8%) vs placebo 28/366 (7.7%) 


Skin (occupational dry skin and irritant contact dermatitis) - 2003
 

Gradual delivery of AV gel to skin by dry-coated Aloe Vera gloves produced improved skin integrity, decreased appearance of fine wrinkling, and decreased erythema in occupational dry skin and irritant contact dermatitis


Stomach & Intestinal Ulcers - 2002

A team from the Barts and London, and Queen Mary's School of Medicineand Dentistry carried out tests which show that Aloe Vera  has a beneficial effect on the production of substances which help boost the healing process in cases of ulceration in the gut. This was carried out on human tissue rather than patients so it was not a clinical trial but is noted here all the same. 


Ulcerative Colitis - 2004 

Aloe Vera appears to be safe and this treatment should be considered as part of a comprehensive approach to the treatment of ulcerative colitis


Irritable Bowel Syndrome - 2002 

This trial was interesting but, unlike the trials cited above, a high drop-out rate rendered its results inconclusive.  (for more on this see the bottom of this page)